Present deep learning tools for animal localization require extensive laborious annotation and
time-consuming training for the creation of setup-specific models, slowing scientific progress.
Additionally, the effectiveness of these tools in naturalistic settings is impeded by visual variability
of objects and environmental diversity, hindering animal detection in complex environments. Our study
presents the ’Detect Any Mouse Model’ (DAMM), a robustly validated object detector designed for localizing
mice in complex environments. DAMM excels in generalization, robustly performing with zero to minimal
additional training on previously unseen setups and multi-animal scenarios. Its integration with the SORT
algorithm permits robust tracking, competitively performing with keypoint-estimation-based tools. These
developments, along with our dissemination of DAMM, mark a significant step forward in streamlining
ethologically-relevant animal behavioral studies.